Cell cycle plasticity driven by MTOR signaling: integral resistance to CDK4/6 inhibition in patient-derived models of pancreatic cancer.

Knudsen, Erik S; Kumarasamy, Vishnu; Ruiz, Amanda; Sivinski, Jared; Chung, Sejin; Grant, Adam; Vail, Paris; Chauhan, Shailender S; Jie, Tun; Riall, Taylor S; Witkiewicz, Agnieszka K

Knudsen, Erik S; Kumarasamy, Vishnu; Ruiz, Amanda; Sivinski, Jared; Chung, Sejin; Grant, Adam; Vail, Paris; Chauhan, Shailender S; Jie, Tun; Riall, Taylor S; Witkiewicz, Agnieszka K.

Afiliação

Knudsen ES; Center for Personalized Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA. Erik.Knudsen@roswellpark.org.
Kumarasamy V; Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY, USA. Erik.Knudsen@roswellpark.org.
Ruiz A; Center for Personalized Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA.
Sivinski J; Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.
Chung S; Center for Personalized Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA.
Grant A; Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.
Vail P; Department of Pharmacology, Universtiy of Arizona, Tucson, AZ, USA.
Chauhan SS; Center for Personalized Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA.
Jie T; Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.
Riall TS; Center for Personalized Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA.
Witkiewicz AK; Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.

Oncogene ; 38(18): 3355-3370, 2019 05.

Article em En | MEDLINE | ID: mdl-30696953

Assuntos

Quinase 4 Dependente de Ciclina/antagonistas & inibidores; Quinase 6 Dependente de Ciclina/antagonistas & inibidores; Neoplasias Pancreáticas/metabolismo; Neoplasias Pancreáticas/patologia; Serina-Treonina Quinases TOR/metabolismo; Animais; Biomarcadores Tumorais/metabolismo; Carcinoma Ductal Pancreático/tratamento farmacológico; Carcinoma Ductal Pancreático/metabolismo; Carcinoma Ductal Pancreático/patologia; Ciclo Celular/fisiologia; Linhagem Celular Tumoral; Plasticidade Celular/fisiologia; Humanos; Camundongos; Neoplasias Pancreáticas/tratamento farmacológico; Prognóstico; Inibidores de Proteínas Quinases/farmacologia; Transdução de Sinais; Regulação para Cima; Ensaios Antitumorais Modelo de Xenoenxerto/métodos

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Quinase 4 Dependente de Ciclina / Quinase 6 Dependente de Ciclina / Serina-Treonina Quinases TOR Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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