A protecting group-free divergent synthesis of natural benzofurans via one-pot synthesis of 2-bromo-6-hydroxybenzofurans.
Org Biomol Chem
; 17(8): 2153-2161, 2019 02 20.
Article
em En
| MEDLINE
| ID: mdl-30702732
ABSTRACT
2-Bromo-6-hydroxybenzofurans are potentially versatile intermediates for the divergent synthesis of numerous benzofuran-based natural products and their analogues. Herein we report the first one-pot strategy for the efficient synthesis of 2-bromo-6-hydroxybenzofurans. The present protocol provides shorter routes for the synthesis of moracins M, N, O and P; gramniphenols F and G; and morunigrol C using a protecting group-free approach.
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MEDLINE
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En
Ano de publicação:
2019
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Article