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Differential Associations of IL-4 With Hippocampal Subfields in Mild Cognitive Impairment and Alzheimer's Disease.
Boccardi, Virginia; Westman, Eric; Pelini, Luca; Lindberg, Olof; Muehlboeck, J-Sebastian; Simmons, Andrew; Tarducci, Roberto; Floridi, Piero; Chiarini, Pietro; Soininen, Hilkka; Kloszewska, Iwona; Tsolaki, Magda; Vellas, Bruno; Spenger, Christian; Wahlund, Lars-Olof; Lovestone, Simon; Mecocci, Patrizia.
Afiliação
  • Boccardi V; Department of Medicine, Institute of Gerontology and Geriatrics, University of Perugia, Perugia, Italy.
  • Westman E; Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
  • Pelini L; Department of Medicine, Institute of Gerontology and Geriatrics, University of Perugia, Perugia, Italy.
  • Lindberg O; Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
  • Muehlboeck JS; Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
  • Simmons A; Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.
  • Tarducci R; Division of Medical Physics, Perugia University Hospital, Perugia, Italy.
  • Floridi P; Division of Neuroradiology, Perugia University Hospital, Perugia, Italy.
  • Chiarini P; Division of Neuroradiology, Perugia University Hospital, Perugia, Italy.
  • Soininen H; Department of Neurology, University of Eastern Finland - Kuopio University Hospital, Kuopio, Finland.
  • Kloszewska I; Department of Old Age Psychiatry and Psychotic Disorders, Medical University of Lódz, Lódz, Poland.
  • Tsolaki M; 3rd Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
  • Vellas B; University of Toulouse, INSERM 1027, Gérontopôle, Toulouse, France.
  • Spenger C; Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
  • Wahlund LO; Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
  • Lovestone S; Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, United Kingdom.
  • Mecocci P; Department of Medicine, Institute of Gerontology and Geriatrics, University of Perugia, Perugia, Italy.
Front Aging Neurosci ; 10: 439, 2018.
Article em En | MEDLINE | ID: mdl-30705627
Background/Aims: We aimed to assess the association between in volumetric measures of hippocampal sub-regions - in healthy older controls (HC), subjects with mild cognitive impairment (MCI) and AD- with circulating levels of IL-4. Methods: From AddNeuroMed Project 113 HC, 101 stable MCI (sMCI), 22 converter MCI (cMCI) and 119 AD were included. Hippocampal subfield volumes were analyzed using Freesurfer 6.0.0 on high-resolution sagittal 3D-T1W MP-RAGE acquisitions. Plasmatic IL-4 was measured using ELISA assay. Results: IL-4 was found to be (a) positively associate with left subiculum volume (ß = 0.226, p = 0.037) in sMCI and (b) negatively associate with left subiculum volume (ß = -0.253, p = 0.011) and left presubiculum volume (ß = -0.257, p = 0.011) in AD. Conclusion: Our results indicate a potential neuroprotective effect of IL-4 on the areas of the hippocampus more vulnerable to aging and neurodegeneration.
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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Ano de publicação: 2018 Tipo de documento: Article