Enantioselective Synthesis of Azamerone.
J Am Chem Soc
; 141(7): 2867-2871, 2019 02 20.
Article
em En
| MEDLINE
| ID: mdl-30707836
ABSTRACT
A concise and selective synthesis of the dichlorinated meroterpenoid azamerone is described. The paucity of tactics for the synthesis of natural-product-relevant chiral organochlorides motivated the development of unique strategies for accessing these motifs in enantioenriched forms. The route features a novel enantioselective chloroetherification reaction, a Pd-catalyzed cross-coupling between a quinone diazide and a boronic hemiester, and a late-stage tetrazine [4+2]-cycloaddition/oxidation cascade.
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Base de dados:
MEDLINE
Assunto principal:
Terpenos
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article