Association of statin pretreatment with collateral circulation and final infarct volume in acute ischemic stroke patients: A meta-analysis.
Atherosclerosis
; 282: 75-79, 2019 03.
Article
em En
| MEDLINE
| ID: mdl-30708178
ABSTRACT
BACKGROUND AND AIMS:
Statin pretreatment (SP) is associated with improved outcomes in acute ischemic stroke (AIS) patients. Collateral circulation status and final infarct volume (FIV) are independent predictors of functional outcome in AIS.METHODS:
We sought to evaluate the association of SP with collateral circulation and FIV in AIS patients. We used a random-effects model for all the analyses, and pooled standardized mean differences (SMDs) and odds ratios (OR) on the FIV and collateral status according to SP history, respectively.RESULTS:
We identified 9 eligible studies (1186 AIS patients). History of SP was associated with lower FIV (SMDâ¯=â¯0.25, 95%CI 0.07-0.42, pâ¯=â¯0.005) compared to negative history of SP. A trend towards good collateral scores was observed in the SP group (ORâ¯=â¯1.45; 95% CI, 0.92-2.29, pâ¯=â¯0.11). Subgroup analysis demonstrated reduced FIV among atherosclerotic stroke patients with history of SP (SMDâ¯=â¯0.49; 95% CI, 0.19-0.80, pâ¯=â¯0.001).CONCLUSIONS:
SP appears to be associated with decreased FIV, especially in atherosclerotic AIS.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Circulação Colateral
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Inibidores de Hidroximetilglutaril-CoA Redutases
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Acidente Vascular Cerebral
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
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Risk_factors_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article