Computerized cognitive training for Chinese mild cognitive impairment patients: A neuropsychological and fMRI study.
Neuroimage Clin
; 22: 101691, 2019.
Article
em En
| MEDLINE
| ID: mdl-30708349
ABSTRACT
BACKGROUND:
Computerized multi-model training has been widely studied for its effect on delaying cognitive decline. In this study, we designed the first Chinese-version computer-based multi-model cognitive training for mild cognitive impairment (MCI) patients. Neuropsychological effects and neural activity changes assessed by functional MRI were both evaluated.METHOD:
MCI patients in the training group were asked to take training 3-4 times per week for 6â¯months. Neuropsychological and resting-state fMRI assessment were performed at baseline and at 6â¯months. Patients in both groups were continuously followed up for another 12â¯months and assessed by neuropsychological tests again.RESULTS:
78 patients in the training group and 63 patients in the control group accomplished 6-month follow-up. Training group improved 0.23 standard deviation (SD) of mini-mental state examination, while control group had 0.5â¯SD decline. Addenbrooke's cognitive examination-revised scores in attention (pâ¯=â¯0.002) and memory (pâ¯=â¯0.006), as well as stroop color-word test interference index (pâ¯=â¯0.038) and complex figure test-copy score (pâ¯=â¯0.035) were also in favor of the training effect. Difference between the changes of two groups after training was not statistically significant. The fMRI showed increased regional activity at bilateral temporal poles, insular cortices and hippocampus. However, difference between the changes of two groups after another 12â¯months was not statistically significant.CONCLUSIONS:
Multi-model cognitive training help MCI patients to gained cognition benefit, especially in memory, attention and executive function. Functional neuroimaging provided consistent neural activation evidence. Nevertheless, after one-year follow up after last training, training effects were not significant. The study provided new evidence of beneficial effect of multi-model cognitive training.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Terapia Assistida por Computador
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Córtex Cerebral
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Disfunção Cognitiva
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Remediação Cognitiva
Tipo de estudo:
Clinical_trials
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Observational_studies
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Prognostic_studies
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article