Curcumin and Cinnamaldehyde as PTP1B Inhibitors With Antidiabetic and Anticancer Potential.
Anticancer Res
; 39(2): 745-749, 2019 Feb.
Article
em En
| MEDLINE
| ID: mdl-30711953
ABSTRACT
BACKGROUND/AIM:
Protein tyrosine phosphatase (PTP1B) is a potential target for the treatment of type 2 diabetes and cancer. Curcumin and cinnamaldehyde have been previously reported to have antidiabetic and anticancer potentials. The aim of this study was to investigate the effect of curcumin in comparison to cinnamaldehyde on the enzymatic activity of PTP1B and the viability of MCF-7 cancer cells. MATERIALS ANDMETHODS:
Enzymatic activity and cell viability assays were utilized. Experiments were performed using the breast cancer MCF-7 cell line.RESULTS:
Curcumin and cinnamaldehyde decreased the activity of PTP1B, and had inhibitory effects on the viability of MCF-7 cancer cells. Curcumin had a significantly higher inhibitory effect than cinnamaldehyde.CONCLUSION:
Curcumin can be considered a potential agent for the treatment of type-2 diabetes or cancer.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Acroleína
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Neoplasias da Mama
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Curcumina
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Diabetes Mellitus Tipo 2
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Proteína Tirosina Fosfatase não Receptora Tipo 1
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Hipoglicemiantes
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Antineoplásicos
Limite:
Female
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Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article