Design, synthesis and evaluations of spiro-fused benzoxaborin derivatives as novel boron-containing compounds.

Natsutani, Itaru; Iwata, Riyo; Yamai, Yu-Suke; Ishida, Kyoji; Nagaoka, Yasuo; Sumiyoshi, Takaaki

Natsutani, Itaru; Iwata, Riyo; Yamai, Yu-Suke; Ishida, Kyoji; Nagaoka, Yasuo; Sumiyoshi, Takaaki.

Afiliação

Natsutani I; Department of Life Science and Biotechnology, Faculty of Chemistry, Materials and Bioengineering, Kansai University, Suita, Osaka, Japan.
Iwata R; Department of Life Science and Biotechnology, Faculty of Chemistry, Materials and Bioengineering, Kansai University, Suita, Osaka, Japan.
Yamai YS; Department of Life Science and Biotechnology, Faculty of Chemistry, Materials and Bioengineering, Kansai University, Suita, Osaka, Japan.
Ishida K; Department of Life Science and Biotechnology, Faculty of Chemistry, Materials and Bioengineering, Kansai University, Suita, Osaka, Japan.
Nagaoka Y; Department of Life Science and Biotechnology, Faculty of Chemistry, Materials and Bioengineering, Kansai University, Suita, Osaka, Japan.
Sumiyoshi T; Department of Life Science and Biotechnology, Faculty of Chemistry, Materials and Bioengineering, Kansai University, Suita, Osaka, Japan.

Chem Biol Drug Des ; 93(5): 657-665, 2019 05.

Article em En | MEDLINE | ID: mdl-30721578

Assuntos

Boro/química; Desenho de Fármacos; Indóis/síntese química; Compostos de Espiro/química; Permeabilidade da Membrana Celular/efeitos dos fármacos; Meia-Vida; Humanos; Indóis/farmacocinética; Indóis/farmacologia; Microssomos Hepáticos/metabolismo

Palavras-chave

benzoxaborin; boron-containing heterocycles; chemical library; oxindole; spiro-fused compounds

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Compostos de Espiro / Boro / Desenho de Fármacos / Indóis Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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