The microtubule-associated protein EML3 regulates mitotic spindle assembly by recruiting the Augmin complex to spindle microtubules.

Luo, Jia; Yang, Biying; Xin, Guangwei; Sun, Mengjie; Zhang, Boyan; Guo, Xiao; Jiang, Qing; Zhang, Chuanmao

Luo, Jia; Yang, Biying; Xin, Guangwei; Sun, Mengjie; Zhang, Boyan; Guo, Xiao; Jiang, Qing; Zhang, Chuanmao.

Afiliação

Luo J; From the Key Laboratory of Cell Proliferation and Differentiation, Ministry of Education, and the State Key Laboratory of Membrane Biology, College of Life Sciences, Peking University, Beijing 100871, China.
Yang B; From the Key Laboratory of Cell Proliferation and Differentiation, Ministry of Education, and the State Key Laboratory of Membrane Biology, College of Life Sciences, Peking University, Beijing 100871, China.
Xin G; From the Key Laboratory of Cell Proliferation and Differentiation, Ministry of Education, and the State Key Laboratory of Membrane Biology, College of Life Sciences, Peking University, Beijing 100871, China.
Sun M; From the Key Laboratory of Cell Proliferation and Differentiation, Ministry of Education, and the State Key Laboratory of Membrane Biology, College of Life Sciences, Peking University, Beijing 100871, China.
Zhang B; From the Key Laboratory of Cell Proliferation and Differentiation, Ministry of Education, and the State Key Laboratory of Membrane Biology, College of Life Sciences, Peking University, Beijing 100871, China.
Guo X; From the Key Laboratory of Cell Proliferation and Differentiation, Ministry of Education, and the State Key Laboratory of Membrane Biology, College of Life Sciences, Peking University, Beijing 100871, China.
Jiang Q; From the Key Laboratory of Cell Proliferation and Differentiation, Ministry of Education, and the State Key Laboratory of Membrane Biology, College of Life Sciences, Peking University, Beijing 100871, China.
Zhang C; From the Key Laboratory of Cell Proliferation and Differentiation, Ministry of Education, and the State Key Laboratory of Membrane Biology, College of Life Sciences, Peking University, Beijing 100871, China zhangcm@pku.edu.cn.

J Biol Chem ; 294(14): 5643-5656, 2019 04 05.

Article em En | MEDLINE | ID: mdl-30723163

Assuntos

Proteínas de Ciclo Celular/metabolismo; Cinetocoros/metabolismo; Proteínas Associadas aos Microtúbulos/metabolismo; Microtúbulos/metabolismo; Fuso Acromático/metabolismo; Substituição de Aminoácidos; Proteínas de Ciclo Celular/genética; Técnicas de Silenciamento de Genes; Células HEK293; Células HeLa; Humanos; Proteínas Associadas aos Microtúbulos/genética; Microtúbulos/genética; Mutação de Sentido Incorreto; Fuso Acromático/genética; Tubulina (Proteína)/genética; Tubulina (Proteína)/metabolismo

Palavras-chave

Augmin; EML3; cell division; checkpoint control; chromosome congression; cytoskeleton; microtubule; microtubule nucleation; microtubule-associated protein (MAP); mitosis; mitotic spindle; spindle assembly

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cinetocoros / Proteínas de Ciclo Celular / Proteínas Associadas aos Microtúbulos / Microtúbulos / Fuso Acromático Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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