Design, synthesis, and screening of novel ursolic acid derivatives as potential anti-cancer agents that target the HIF-1&#945; pathway.

Wu, Jie; Zhang, Zhi-Hong; Zhang, Lin-Hao; Jin, Xue-Jun; Ma, Juan; Piao, Hu-Ri

Design, synthesis, and screening of novel ursolic acid derivatives as potential anti-cancer agents that target the HIF-1α pathway.

Wu, Jie; Zhang, Zhi-Hong; Zhang, Lin-Hao; Jin, Xue-Jun; Ma, Juan; Piao, Hu-Ri.

Afiliação

Wu J; Key Laboratory of Natural Resources of Changbai Mountain & Functional Molecules, Ministry of Education, Yanbian University College of Pharmacy, Yanji 133002, China.
Zhang ZH; Key Laboratory of Natural Resources of Changbai Mountain & Functional Molecules, Ministry of Education, Yanbian University College of Pharmacy, Yanji 133002, China.
Zhang LH; Key Laboratory of Natural Resources of Changbai Mountain & Functional Molecules, Ministry of Education, Yanbian University College of Pharmacy, Yanji 133002, China.
Jin XJ; Key Laboratory of Natural Resources of Changbai Mountain & Functional Molecules, Ministry of Education, Yanbian University College of Pharmacy, Yanji 133002, China.
Ma J; Key Laboratory of Natural Resources of Changbai Mountain & Functional Molecules, Ministry of Education, Yanbian University College of Pharmacy, Yanji 133002, China. Electronic address: majuan@ybu.edu.cn.
Piao HR; Key Laboratory of Natural Resources of Changbai Mountain & Functional Molecules, Ministry of Education, Yanbian University College of Pharmacy, Yanji 133002, China. Electronic address: piaohr@ybu.edu.cn.

Bioorg Med Chem Lett ; 29(6): 853-858, 2019 03 15.

Article em En | MEDLINE | ID: mdl-30728113

Assuntos

Antineoplásicos/farmacologia; Subunidade alfa do Fator 1 Induzível por Hipóxia/metabolismo; Transdução de Sinais/efeitos dos fármacos; Triterpenos/farmacologia; Antineoplásicos/síntese química; Antineoplásicos/química; Linhagem Celular Tumoral; Desenho de Fármacos; Humanos; Estrutura Molecular; RNA Mensageiro/metabolismo; Relação Estrutura-Atividade; Triterpenos/síntese química; Triterpenos/química; Fator A de Crescimento do Endotélio Vascular/genética

Palavras-chave

Aminoguanidine; Anticancer activity; Cytotoxicity; HIF-1α inhibitor; Ursolic acid

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Triterpenos / Transdução de Sinais / Subunidade alfa do Fator 1 Induzível por Hipóxia / Antineoplásicos Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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