Inflammasome Inhibition Links IRGM to Innate Immunity.
Mol Cell
; 73(3): 391-392, 2019 02 07.
Article
em En
| MEDLINE
| ID: mdl-30735651
ABSTRACT
IRGM is a risk factor for several inflammatory diseases, yet no direct link to immune regulation had been shown. In this issue of Molecular Cell, Mehto et al. (2019) report that IRGM limits NLRP3 inflammasome activation-by both direct inhibition of NLRP3/ASC oligomerization and selective autophagic destruction of NLRP3/ASC.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Autofagia
/
Doença de Crohn
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article