Cytotoxic lycodine alkaloids from the aerial parts of Lycopodiastrum casuarinoides.
J Asian Nat Prod Res
; 22(3): 217-224, 2020 Mar.
Article
em En
| MEDLINE
| ID: mdl-30740993
ABSTRACT
A phytochemical investigation on the 75% EtOH extract of the aerial parts of Lycopodiastrum casuarinoides resulted in the isolation of three new lycodine alkaloids, 16-hydroxy-9-oxo-lycocasuarinine D (1), 6α-hydroxy-16-dehydroxy-lycocasuarinine A (2), and 6α,16-dihydroxy-lycocasuarinine B (3). Structural elucidation of all the compounds was performed by spectral methods such as 1D- and 2D-NMR, infrared, ultraviolet, and HR-ESI-MS. The isolated alkaloids were tested in vitro for cytotoxic potential against six lung cancer cell lines. Consequently, alkaloid 1 exhibited cytotoxicity against all the tested tumor cell lines with IC50 values less than 20 µM.[Formula see text].
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1
Base de dados:
MEDLINE
Assunto principal:
Inibidores da Colinesterase
/
Alcaloides
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article