Regulation and role of endoglin in cholesterol-induced endothelial and vascular dysfunction <i>in vivo</i> and <i>in vitro</i>.

Vicen, Matej; Vitverova, Barbora; Havelek, Radim; Blazickova, Katerina; Machacek, Miloslav; Rathouska, Jana; Najmanová, Iveta; Dolezelova, Eva; Prasnicka, Alena; Sternak, Magdalena; Bernabeu, Carmelo; Nachtigal, Petr

Regulation and role of endoglin in cholesterol-induced endothelial and vascular dysfunction in vivo and in vitro.

Vicen, Matej; Vitverova, Barbora; Havelek, Radim; Blazickova, Katerina; Machacek, Miloslav; Rathouska, Jana; Najmanová, Iveta; Dolezelova, Eva; Prasnicka, Alena; Sternak, Magdalena; Bernabeu, Carmelo; Nachtigal, Petr.

Afiliação

Vicen M; Department of Biological and Medical Sciences, Faculty of Pharmacy in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic.
Vitverova B; Department of Biological and Medical Sciences, Faculty of Pharmacy in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic.
Havelek R; Department of Medical Biochemistry, Faculty of Medicine in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic.
Blazickova K; Department of Biological and Medical Sciences, Faculty of Pharmacy in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic.
Machacek M; Department of Biochemical Sciences, Faculty of Pharmacy in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic.
Rathouska J; Department of Biological and Medical Sciences, Faculty of Pharmacy in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic.
Najmanová I; Department of Biological and Medical Sciences, Faculty of Pharmacy in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic.
Dolezelova E; Department of Biological and Medical Sciences, Faculty of Pharmacy in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic.
Prasnicka A; Department of Biological and Medical Sciences, Faculty of Pharmacy in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic.
Sternak M; Jagiellonian Centre for Experimental Therapeutics (JCET), Bobrzynskiego, Krakow, Poland.
Bernabeu C; Center for Biological Research, Spanish National Research Council (CSIC), Madrid, Spain.
Nachtigal P; Biomedical Research Networking Center on Rare Diseases (CIBERER), Madrid, Spain.

FASEB J ; 33(5): 6099-6114, 2019 05.

Article em En | MEDLINE | ID: mdl-30753095

Assuntos

Endoglina/metabolismo; Endotélio Vascular/metabolismo; Hipercolesterolemia/metabolismo; Placa Aterosclerótica/metabolismo; Animais; Aorta/citologia; Aorta/metabolismo; Aorta/patologia; Apolipoproteínas E/genética; Células Cultivadas; Colesterol/metabolismo; Endoglina/genética; Endotélio Vascular/efeitos dos fármacos; Endotélio Vascular/patologia; Feminino; Humanos; Hipercolesterolemia/complicações; Hipercolesterolemia/genética; Indazóis/farmacologia; Ácidos Isonicotínicos/farmacologia; Fator 6 Semelhante a Kruppel/metabolismo; Camundongos; Camundongos Endogâmicos C57BL; NF-kappa B/metabolismo; Óxido Nítrico/metabolismo; Óxido Nítrico Sintase Tipo III/metabolismo; Selectina-P/metabolismo; Placa Aterosclerótica/etiologia; Placa Aterosclerótica/genética; Receptores de LDL/genética; Proteínas Smad/metabolismo; beta-Ciclodextrinas/farmacologia

Palavras-chave

endothelial cells; hypercholesterolemia; mice; oxysterols

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Endotélio Vascular / Placa Aterosclerótica / Endoglina / Hipercolesterolemia Tipo de estudo: Etiology_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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