Your browser doesn't support javascript.
loading
Dystroglycan is a scaffold for extracellular axon guidance decisions.
Lindenmaier, L Bailey; Parmentier, Nicolas; Guo, Caiying; Tissir, Fadel; Wright, Kevin M.
Afiliação
  • Lindenmaier LB; Vollum Institute, Oregon Health & Science University, Portland, United States.
  • Parmentier N; Institiute of Neuroscience, Université Catholique de Louvain, Brussels, Belgium.
  • Guo C; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.
  • Tissir F; Institiute of Neuroscience, Université Catholique de Louvain, Brussels, Belgium.
  • Wright KM; Vollum Institute, Oregon Health & Science University, Portland, United States.
Elife ; 82019 02 13.
Article em En | MEDLINE | ID: mdl-30758284
Axon guidance requires interactions between extracellular signaling molecules and transmembrane receptors, but how appropriate context-dependent decisions are coordinated outside the cell remains unclear. Here we show that the transmembrane glycoprotein Dystroglycan interacts with a changing set of environmental cues that regulate the trajectories of extending axons throughout the mammalian brain and spinal cord. Dystroglycan operates primarily as an extracellular scaffold during axon guidance, as it functions non-cell autonomously and does not require signaling through its intracellular domain. We identify the transmembrane receptor Celsr3/Adgrc3 as a binding partner for Dystroglycan, and show that this interaction is critical for specific axon guidance events in vivo. These findings establish Dystroglycan as a multifunctional scaffold that coordinates extracellular matrix proteins, secreted cues, and transmembrane receptors to regulate axon guidance.
Assuntos
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Distroglicanas / Espaço Extracelular / Orientação de Axônios Tipo de estudo: Guideline / Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Distroglicanas / Espaço Extracelular / Orientação de Axônios Tipo de estudo: Guideline / Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article