Synthesis of quinazolin-4(1H)-ones via amination and annulation of amidines and benzamides.
Org Biomol Chem
; 17(9): 2356-2360, 2019 02 27.
Article
em En
| MEDLINE
| ID: mdl-30758386
ABSTRACT
Quinazolinones have broad applications in the biological, pharmaceutical and material fields. Studies on the synthesis of these compounds are therefore widely conducted. Herein, a novel and highly efficient copper-mediated tandem C(sp2)-H amination and annulation of benzamides and amidines for the synthesis of quinazolin-4(1H)-ones is proposed. This synthetic route can be useful for the construction of quinazolin-4(1H)-one frameworks.
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MEDLINE
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En
Ano de publicação:
2019
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Article