Improvement of antibody functionality by structure-guided paratope engraftment.

Liu, Qingbo; Lai, Yen-Ting; Zhang, Peng; Louder, Mark K; Pegu, Amarendra; Rawi, Reda; Asokan, Mangaiarkarasi; Chen, Xuejun; Shen, Chen-Hsiang; Chuang, Gwo-Yu; Yang, Eun Sung; Miao, Huiyi; Wang, Yuge; Fauci, Anthony S; Kwong, Peter D; Mascola, John R; Lusso, Paolo

Liu, Qingbo; Lai, Yen-Ting; Zhang, Peng; Louder, Mark K; Pegu, Amarendra; Rawi, Reda; Asokan, Mangaiarkarasi; Chen, Xuejun; Shen, Chen-Hsiang; Chuang, Gwo-Yu; Yang, Eun Sung; Miao, Huiyi; Wang, Yuge; Fauci, Anthony S; Kwong, Peter D; Mascola, John R; Lusso, Paolo.

Afiliação

Liu Q; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, 20892, USA.
Lai YT; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, 20892, USA.
Zhang P; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, 20892, USA.
Louder MK; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, 20892, USA.
Pegu A; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, 20892, USA.
Rawi R; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, 20892, USA.
Asokan M; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, 20892, USA.
Chen X; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, 20892, USA.
Shen CH; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, 20892, USA.
Chuang GY; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, 20892, USA.
Yang ES; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, 20892, USA.
Miao H; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, 20892, USA.
Wang Y; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, 20892, USA.
Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, 20892, USA.
Kwong PD; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, 20892, USA.
Mascola JR; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, 20892, USA.
Lusso P; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, 20892, USA. plusso@niaid.nih.gov.

Nat Commun ; 10(1): 721, 2019 02 13.

Article em En | MEDLINE | ID: mdl-30760721

Assuntos

Anticorpos Neutralizantes/química; Anticorpos Neutralizantes/imunologia; Sítios de Ligação de Anticorpos/imunologia; Infecções por HIV/imunologia; HIV-1/imunologia; Animais; Anticorpos Neutralizantes/genética; Sítios de Ligação de Anticorpos/genética; Modelos Animais de Doenças; Mapeamento de Epitopos; Epitopos; Feminino; Células HEK293; Anticorpos Anti-HIV/química; Anticorpos Anti-HIV/imunologia; Proteína gp120 do Envelope de HIV/química; Proteína gp120 do Envelope de HIV/genética; Proteína gp120 do Envelope de HIV/imunologia; Infecções por HIV/prevenção & controle; Humanos; Região Variável de Imunoglobulina/química; Região Variável de Imunoglobulina/genética; Região Variável de Imunoglobulina/imunologia; Macaca mulatta; Camundongos; Camundongos Transgênicos; Modelos Moleculares; Mutagênese Sítio-Dirigida; Conformação Proteica

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sítios de Ligação de Anticorpos / Infecções por HIV / HIV-1 / Anticorpos Neutralizantes Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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