Relationship between plasma YKL-40 levels and endothelial dysfunction in chronic kidney disease
Turk J Med Sci
; 49(1): 139-146, 2019 Feb 11.
Article
em En
| MEDLINE
| ID: mdl-30763987
ABSTRACT
Background/aim:
We aimed to evaluate the relationship between YKL-40 and endothelial dysfunction in chronic kidney disease. Materials andmethods:
Twenty-nine hemodialysis patients, 101 patients with nondialytic (stage 2, 3, 4, and 5 ND) chronic kidney disease (CKD), and 38 healthy individuals as a control group were included. YKL-40 levels were measured by ELISA. Endothelial dysfunction was indirectly measured by flow-mediated dilatation percentage (FMD) in the brachial artery.YKL-40 levels were higher in CKD patients than controls and highest in HD patients (P = 0.001). FMD values were lower in nondialytic CKD patients and lowest in HD patients (P = 0.001). YKL-40 negatively correlated with eGFR and FMD values (r = 0.674 and r = 0.471, respectively).This study shows that YKL-40 increases with CKD stage and is negatively correlated with FMD measurementsPalavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vasodilatação
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Endotélio Vascular
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Diálise Renal
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Insuficiência Renal Crônica
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Proteína 1 Semelhante à Quitinase-3
Tipo de estudo:
Diagnostic_studies
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article