Regions of homozygosity as risk factors for multiple myeloma.
Ann Hum Genet
; 83(4): 231-238, 2019 07.
Article
em En
| MEDLINE
| ID: mdl-30768683
ABSTRACT
Genomic regions of homozygosity (ROH), detectable in outbred populations, have been implicated as determinants of inherited risk. To examine whether ROH is associated with risk of multiple myeloma (MM), we performed whole-genome homozygosity analysis using single-nucleotide polymorphism genotype data from 2,282 MM cases and 5,197 controls, with replication in an additional 878 MM cases and 7,083 controls. Globally, the distribution of ROH between cases and controls was not significantly different. However, one ROH at chromosome 9q21, harboring the B-cell transcription factor gene KLF9, showed evidence of a consistent association and may therefore warrant further investigation as a candidate risk factor for MM. Overall, our analysis provides little support for a homozygosity signature being a significant factor in MM risk.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Predisposição Genética para Doença
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Alelos
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Estudos de Associação Genética
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Homozigoto
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Mieloma Múltiplo
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Humans
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Middle aged
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article