IR, Raman and SERS analysis of amikacin combined with DFT-based calculations.
Spectrochim Acta A Mol Biomol Spectrosc
; 214: 79-85, 2019 May 05.
Article
em En
| MEDLINE
| ID: mdl-30769154
ABSTRACT
Amikacin, a molecule formed by two glucosamine rings linked by α-linkages through a central deoxystreptamine, is an antibiotic often used in clinical treatments, with a special attention in the pediatric cases, due to the physiological activity of their renal system. In spite of its extensive use, no detailed information about the vibrational features of the molecule is available in the literature. Thus, in this study we performed a comprehensive vibrational investigation of amikacin from both an experimental and theoretical point of view. Raman and IR spectroscopy combined with DFT calculations conducted to a complete vibrational characterization of the molecule, with the assignment of the vibrational modes. Moreover, SERS spectrum was recorded and analyzed and provided information about the adsorption behavior of the amikacin on the silver nanoparticles surface.
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Base de dados:
MEDLINE
Assunto principal:
Amicacina
/
Modelos Moleculares
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article