Your browser doesn't support javascript.
loading
Human CD8+ T cell cross-reactivity across influenza A, B and C viruses.
Koutsakos, Marios; Illing, Patricia T; Nguyen, Thi H O; Mifsud, Nicole A; Crawford, Jeremy Chase; Rizzetto, Simone; Eltahla, Auda A; Clemens, E Bridie; Sant, Sneha; Chua, Brendon Y; Wong, Chinn Yi; Allen, E Kaitlynn; Teng, Don; Dash, Pradyot; Boyd, David F; Grzelak, Ludivine; Zeng, Weiguang; Hurt, Aeron C; Barr, Ian; Rockman, Steve; Jackson, David C; Kotsimbos, Tom C; Cheng, Allen C; Richards, Michael; Westall, Glen P; Loudovaris, Thomas; Mannering, Stuart I; Elliott, Michael; Tangye, Stuart G; Wakim, Linda M; Rossjohn, Jamie; Vijaykrishna, Dhanasekaran; Luciani, Fabio; Thomas, Paul G; Gras, Stephanie; Purcell, Anthony W; Kedzierska, Katherine.
Afiliação
  • Koutsakos M; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.
  • Illing PT; Infection and Immunity Program & Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
  • Nguyen THO; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.
  • Mifsud NA; Infection and Immunity Program & Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
  • Crawford JC; Department of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA.
  • Rizzetto S; School of Medical Sciences and The Kirby Institute, UNSW, Sydney, New South Wales, Australia.
  • Eltahla AA; School of Medical Sciences and The Kirby Institute, UNSW, Sydney, New South Wales, Australia.
  • Clemens EB; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.
  • Sant S; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.
  • Chua BY; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.
  • Wong CY; Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan.
  • Allen EK; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.
  • Teng D; Department of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA.
  • Dash P; Infection and Immunity Program & Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
  • Boyd DF; Department of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA.
  • Grzelak L; Department of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA.
  • Zeng W; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.
  • Hurt AC; Biology Department, École Normale Supérieure Paris-Saclay, Université Paris-Saclay, Cachan, France.
  • Barr I; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.
  • Rockman S; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.
  • Jackson DC; World Health Organization (WHO) Collaborating Centre for Reference and Research on Influenza, at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
  • Kotsimbos TC; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.
  • Cheng AC; World Health Organization (WHO) Collaborating Centre for Reference and Research on Influenza, at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
  • Richards M; School of Applied Biomedical Sciences, Federation University, Churchill, Victoria, Australia.
  • Westall GP; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.
  • Loudovaris T; Seqirus, Parkville, Victoria, Australia.
  • Mannering SI; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.
  • Elliott M; Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan.
  • Tangye SG; Department of Allergy, Immunology and Respiratory Medicine, The Alfred Hospital, Melbourne, Victoria, Australia.
  • Wakim LM; Department of Medicine, Monash University, Central Clinical School, The Alfred Hospital, Melbourne, Victoria, Australia.
  • Rossjohn J; School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
  • Vijaykrishna D; Infection Prevention and Healthcare Epidemiology Unit, Alfred Health, Melbourne, Victoria, Australia.
  • Luciani F; Victorian Infectious Diseases Service, The Royal Melbourne Hospital, at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.
  • Thomas PG; Lung Transplant Unit, Alfred Hospital, Melbourne, Victoria, Australia.
  • Gras S; Immunology and Diabetes Unit, St Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia.
  • Purcell AW; Lung Transplant Unit, Alfred Hospital, Melbourne, Victoria, Australia.
  • Kedzierska K; Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.
Nat Immunol ; 20(5): 613-625, 2019 05.
Article em En | MEDLINE | ID: mdl-30778243
ABSTRACT
Influenza A, B and C viruses (IAV, IBV and ICV, respectively) circulate globally and infect humans, with IAV and IBV causing the most severe disease. CD8+ T cells confer cross-protection against IAV strains, however the responses of CD8+ T cells to IBV and ICV are understudied. We investigated the breadth of CD8+ T cell cross-recognition and provide evidence of CD8+ T cell cross-reactivity across IAV, IBV and ICV. We identified immunodominant CD8+ T cell epitopes from IBVs that were protective in mice and found memory CD8+ T cells directed against universal and influenza-virus-type-specific epitopes in the blood and lungs of healthy humans. Lung-derived CD8+ T cells displayed tissue-resident memory phenotypes. Notably, CD38+Ki67+CD8+ effector T cells directed against novel epitopes were readily detected in IAV- or IBV-infected pediatric and adult subjects. Our study introduces a new paradigm whereby CD8+ T cells confer unprecedented cross-reactivity across all influenza viruses, a key finding for the design of universal vaccines.
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vírus da Influenza A / Vírus da Influenza B / Gammainfluenzavirus / Linfócitos T CD8-Positivos / Reações Cruzadas / Influenza Humana Tipo de estudo: Prognostic_studies Limite: Adolescent / Adult / Aged / Animals / Child / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vírus da Influenza A / Vírus da Influenza B / Gammainfluenzavirus / Linfócitos T CD8-Positivos / Reações Cruzadas / Influenza Humana Tipo de estudo: Prognostic_studies Limite: Adolescent / Adult / Aged / Animals / Child / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article