Radiotherapy for benign head and neck paragangliomas.
Head Neck
; 41(7): 2107-2110, 2019 07.
Article
em En
| MEDLINE
| ID: mdl-30779406
ABSTRACT
PURPOSE:
To update our experience treating benign head-and-neck paragangliomas (PGs) with radiotherapy (RT).METHODS:
A total of 149 patients with 176 PGs received curative-intent RT; 126 received RT to 1 PG and 23 to 2 or more PGs. The most common dose fractionation schedule was 45 Gy/25 once-daily fractions/5 weeks which was used to treat 147 PGs (83.5%) in 123 patients (82.6%). Patients were followed with physical examination and CT/MRI. The median follow-up for all patients was 10.6 years (range, 0.2-50.4 years); the median follow-up for surviving patients was 11.1 years (range, 0.2-50.4).RESULTS:
The 5-year, 10-year, and 15-year outcomes were local control, 99%, 96%, and 95%; distant metastasis-free survival, 99%, 99%, and 99%; cause-specific survival, 98%, 98%, and 98%; and overall survival, 90%, 75%, and 64%, respectively. No patient developed a moderate or severe complication, or a radiation-induced second tumor or malignant transformation of the benign PG.CONCLUSION:
RT is an effective treatment for head-and-neck PGs with a low risk of complications.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Paraganglioma Extrassuprarrenal
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Neoplasias de Cabeça e Pescoço
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article