Focal TLR4 activation mediates disturbed flow-induced endothelial inflammation.

Qu, Dan; Wang, Li; Huo, Mingyu; Song, Wencong; Lau, Chi-Wai; Xu, Jian; Xu, Aimin; Yao, Xiaoqiang; Chiu, Jeng-Jiann; Tian, Xiao Yu; Huang, Yu

Qu, Dan; Wang, Li; Huo, Mingyu; Song, Wencong; Lau, Chi-Wai; Xu, Jian; Xu, Aimin; Yao, Xiaoqiang; Chiu, Jeng-Jiann; Tian, Xiao Yu; Huang, Yu.

Afiliação

Qu D; Shenzhen Research Institute, Institute of Vascular Medicine and Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China.
Wang L; Shenzhen Research Institute, Institute of Vascular Medicine and Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China.
Huo M; Shenzhen Research Institute, Institute of Vascular Medicine and Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China.
Song W; Shenzhen Research Institute, Institute of Vascular Medicine and Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China.
Lau CW; Shenzhen Research Institute, Institute of Vascular Medicine and Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China.
Xu J; Shenzhen Research Institute, Institute of Vascular Medicine and Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China.
Xu A; State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong, China.
Yao X; Shenzhen Research Institute, Institute of Vascular Medicine and Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China.
Chiu JJ; Institute of Cellular and System Medicine, National Health Research Institutes, Miaoli, Taiwan.
Tian XY; Shenzhen Research Institute, Institute of Vascular Medicine and Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China.
Huang Y; Shenzhen Research Institute, Institute of Vascular Medicine and Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China.

Cardiovasc Res ; 116(1): 226-236, 2020 01 01.

Article em En | MEDLINE | ID: mdl-30785200

Assuntos

Aterosclerose/metabolismo; Artérias Carótidas/metabolismo; Células Endoteliais/metabolismo; Inflamação/metabolismo; Receptor 4 Toll-Like/metabolismo; Animais; Aterosclerose/genética; Aterosclerose/fisiopatologia; Velocidade do Fluxo Sanguíneo; Artérias Carótidas/fisiopatologia; Artérias Carótidas/cirurgia; Doenças das Artérias Carótidas/genética; Doenças das Artérias Carótidas/metabolismo; Doenças das Artérias Carótidas/fisiopatologia; Adesão Celular; Células Cultivadas; Técnicas de Cocultura; Modelos Animais de Doenças; Fibronectinas/metabolismo; Células Endoteliais da Veia Umbilical Humana/metabolismo; Humanos; Inflamação/genética; Inflamação/fisiopatologia; Ligantes; Ligadura; Mecanotransdução Celular; Camundongos Endogâmicos C57BL; Camundongos Mutantes; Monócitos/metabolismo; Estresse Mecânico; Receptor 4 Toll-Like/genética

Palavras-chave

Atherosclerosis; Endothelial inflammation; Fibronectin; Shear stress; Toll-like receptor 4

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Artérias Carótidas / Células Endoteliais / Aterosclerose / Receptor 4 Toll-Like / Inflamação Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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