Giant Congenital Melanocytic Nevus Treated With Trametinib.
Pediatrics
; 143(3)2019 03.
Article
em En
| MEDLINE
| ID: mdl-30792255
ABSTRACT
Giant congenital nevi are melanocytic proliferations of the skin that may be complicated by melanoma, neurocutaneous melanocytosis, pain, pruritus, and disfigurement. Current treatment options include surgical resection and medical management of associated symptoms. There is limited efficacy in these modalities. No effective pharmacologic treatments are available for the treatment of these lesions. We present the case of a 7-year-old girl with a giant congenital melanocytic nevus that had an AKAP9-BRAF fusion and was treated with trametinib, which resulted in rapid resolution of the patient's lifelong, intractable pain and pruritus as well as dramatic improvement in the extent of her nevus.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Piridonas
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Pirimidinonas
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Neoplasias Cutâneas
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Nevo Pigmentado
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Antineoplásicos
Limite:
Child
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Female
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Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article