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A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels.
Schewe, Marcus; Sun, Han; Mert, Ümit; Mackenzie, Alexandra; Pike, Ashley C W; Schulz, Friederike; Constantin, Cristina; Vowinkel, Kirsty S; Conrad, Linus J; Kiper, Aytug K; Gonzalez, Wendy; Musinszki, Marianne; Tegtmeier, Marie; Pryde, David C; Belabed, Hassane; Nazare, Marc; de Groot, Bert L; Decher, Niels; Fakler, Bernd; Carpenter, Elisabeth P; Tucker, Stephen J; Baukrowitz, Thomas.
Afiliação
  • Schewe M; Institute of Physiology, Christian-Albrechts University of Kiel, 24118 Kiel, Germany. m.schewe@physiologie.uni-kiel.de t.baukrowitz@physiologie.uni-kiel.de.
  • Sun H; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Department of Structural Biology, 13125 Berlin, Germany.
  • Mert Ü; Institute of Physiology, Christian-Albrechts University of Kiel, 24118 Kiel, Germany.
  • Mackenzie A; Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK.
  • Pike ACW; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford OX1 3PN, UK.
  • Schulz F; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford OX1 3PU, UK.
  • Constantin C; Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK.
  • Vowinkel KS; Institute of Physiology, Christian-Albrechts University of Kiel, 24118 Kiel, Germany.
  • Conrad LJ; Institute of Physiology II, Albert-Ludwigs University of Freiburg, 79104 Freiburg, Germany.
  • Kiper AK; Centers for Biological Signaling Studies CIBSS and BIOSS, 79104 Freiburg, Germany.
  • Gonzalez W; Institute of Physiology and Pathophysiology, Vegetative Physiology, Philipps-University of Marburg, 35037 Marburg, Germany.
  • Musinszki M; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford OX1 3PN, UK.
  • Tegtmeier M; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford OX1 3PU, UK.
  • Pryde DC; Institute of Physiology and Pathophysiology, Vegetative Physiology, Philipps-University of Marburg, 35037 Marburg, Germany.
  • Belabed H; Centro de Bioinformatica y Simulacion Molecular, Universidad de Talca, 3465548 Talca, Chile.
  • Nazare M; Millennium Nucleus of Ion Channels-Associated Diseases (MiNICAD), Universidad de Talca, 3465548 Talca, Chile.
  • de Groot BL; Institute of Physiology, Christian-Albrechts University of Kiel, 24118 Kiel, Germany.
  • Decher N; Institute of Physiology, Christian-Albrechts University of Kiel, 24118 Kiel, Germany.
  • Fakler B; Pfizer Worldwide Medicinal Chemistry, Neuroscience and Pain Research Unit, Portway Building, Granta Park, Great Abington, Cambridgeshire CB21 6GS, UK.
  • Carpenter EP; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Department of Medicinal Chemistry, 13125 Berlin, Germany.
  • Tucker SJ; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Department of Medicinal Chemistry, 13125 Berlin, Germany.
  • Baukrowitz T; Computational Biomolecular Dynamics Group, Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany.
Science ; 363(6429): 875-880, 2019 02 22.
Article em En | MEDLINE | ID: mdl-30792303
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tetra-Hidronaftalenos / Tetrazóis / Tioureia / Ativação do Canal Iônico / Clorobenzenos / Canais de Potássio Ativados por Cálcio de Condutância Alta / Ortoaminobenzoatos / Canal de Potássio ERG1 Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tetra-Hidronaftalenos / Tetrazóis / Tioureia / Ativação do Canal Iônico / Clorobenzenos / Canais de Potássio Ativados por Cálcio de Condutância Alta / Ortoaminobenzoatos / Canal de Potássio ERG1 Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article