Safety and tolerability of anifrolumab, a monoclonal antibody targeting type I interferon receptor, in Japanese patients with systemic lupus erythematosus: A multicenter, phase 2, open-label study.

Tanaka, Yoshiya; Takeuchi, Tsutomu; Okada, Masato; Ishii, Tomonori; Nakajima, Hiroshi; Kawai, Shinichi; Nagashima, Takao; Hayashi, Nobuya; Wang, Liangwei; Tummala, Raj

Tanaka, Yoshiya; Takeuchi, Tsutomu; Okada, Masato; Ishii, Tomonori; Nakajima, Hiroshi; Kawai, Shinichi; Nagashima, Takao; Hayashi, Nobuya; Wang, Liangwei; Tummala, Raj.

Afiliação

Tanaka Y; First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan.
Takeuchi T; Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Okada M; Division of Allergy & Rheumatology, St. Luke's International Hospital, Tokyo, Japan.
Ishii T; Department of Rheumatology and Hematology, Tohoku University Hospital, Miyagi, Japan.
Nakajima H; Department of Allergy and Clinical Immunology, Chiba University Hospital, Chiba, Japan.
Kawai S; Department of Inflammation & Pain Control Research, Toho University School of Medicine, Tokyo, Japan.
Nagashima T; Division of Rheumatology and Clinical Immunology, Department of Medicine, Jichi Medical University, Tochigi, Japan.
Hayashi N; Research and Development, AstraZeneca K.K., Osaka, Japan.
Wang L; Global Medicine Division, AstraZeneca Pharmaceuticals, Gaithersburg, MD, USA.
Tummala R; Global Medicine Division, AstraZeneca Pharmaceuticals, Gaithersburg, MD, USA.

Mod Rheumatol ; 30(1): 101-108, 2020 Jan.

Article em En | MEDLINE | ID: mdl-30793642

Assuntos

Anticorpos Monoclonais Humanizados/administração & dosagem; Lúpus Eritematoso Sistêmico/tratamento farmacológico; Receptor de Interferon alfa e beta/imunologia; Adulto; Relação Dose-Resposta a Droga; Feminino; Humanos; Injeções Intravenosas; Japão; Masculino; Pessoa de Meia-Idade; Resultado do Tratamento

Palavras-chave

Anifrolumab; dose escalation; intravenous; safety; systemic lupus erythematosus

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptor de Interferon alfa e beta / Anticorpos Monoclonais Humanizados / Lúpus Eritematoso Sistêmico Tipo de estudo: Clinical_trials Limite: Adult / Female / Humans / Male / Middle aged País como assunto: Asia Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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