Bialternacins A-F, Aromatic Polyketide Dimers from an Endophytic Alternaria sp.
J Nat Prod
; 82(4): 792-797, 2019 04 26.
Article
em En
| MEDLINE
| ID: mdl-30794407
ABSTRACT
Six novel aromatic polyketide dimers, bialternacins A-F (1-6), were isolated from a plant endophytic Alternaria sp. The structures of compounds 1-6 were elucidated on the basis of extensive spectroscopic analysis, single-crystal X-ray diffraction, and electronic circular dichroism analysis. Compounds 1, 2, 5, and 6 were characterized as four pairs of racemic mixtures. Compound (+)-5 was demonstrated to show acetylcholinesterase inhibitory activity with an IC50 value of 15.5 µM. A putative biosynthetic pathway for these compounds was proposed.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Alternaria
/
Policetídeos
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article