C-reactive protein exacerbates epithelial-mesenchymal transition through Wnt/ß-catenin and ERK signaling in streptozocin-induced diabetic nephropathy.

Zhang, Lin; Shen, Zhi-Yuan; Wang, Ke; Li, Wei; Shi, Jing-Ming; Osoro, Ezra Kombo; Ullah, Naeem; Zhou, Yan; Ji, Shang-Rong

Zhang, Lin; Shen, Zhi-Yuan; Wang, Ke; Li, Wei; Shi, Jing-Ming; Osoro, Ezra Kombo; Ullah, Naeem; Zhou, Yan; Ji, Shang-Rong.

Afiliação

Zhang L; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, China.
Shen ZY; Ministry of Education (MOE) Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou, China.
Wang K; Ministry of Education (MOE) Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou, China.
Li W; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, China.
Shi JM; Department of Anatomy, School of Basic Medical Sciences, Xizang Minzu University, Xianyang, China.
Osoro EK; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, China.
Ullah N; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, China.
Zhou Y; Department of Dermatology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Ji SR; Ministry of Education (MOE) Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou, China.

FASEB J ; 33(5): 6551-6563, 2019 05.

Article em En | MEDLINE | ID: mdl-30794428

Assuntos

Proteína C-Reativa/metabolismo; Diabetes Mellitus Experimental/metabolismo; Nefropatias Diabéticas/metabolismo; Transição Epitelial-Mesenquimal; Sistema de Sinalização das MAP Quinases; Via de Sinalização Wnt; Animais; Proteína C-Reativa/genética; Diabetes Mellitus Experimental/genética; Diabetes Mellitus Experimental/patologia; Nefropatias Diabéticas/genética; Nefropatias Diabéticas/patologia; Humanos; Ratos; Ratos Sprague-Dawley; Ratos Transgênicos; beta Catenina/genética; beta Catenina/metabolismo

Palavras-chave

apoptotic cells; cell remodeling; diabetic kidney disease; mesenchymal fibrosis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteína C-Reativa / Sistema de Sinalização das MAP Quinases / Diabetes Mellitus Experimental / Nefropatias Diabéticas / Transição Epitelial-Mesenquimal / Via de Sinalização Wnt Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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