Design and development of novel N-(pyrimidin-2-yl)-1,3,4-oxadiazole hybrids to treat cognitive dysfunctions.

Tripathi, Prabhash Nath; Srivastava, Pavan; Sharma, Piyoosh; Seth, Ankit; Shrivastava, Sushant K

Tripathi, Prabhash Nath; Srivastava, Pavan; Sharma, Piyoosh; Seth, Ankit; Shrivastava, Sushant K.

Afiliação

Tripathi PN; Pharmaceutical Chemistry Research Laboratory, Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi 221 005, India.
Srivastava P; Pharmaceutical Chemistry Research Laboratory, Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi 221 005, India.
Sharma P; Pharmaceutical Chemistry Research Laboratory, Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi 221 005, India.
Seth A; Pharmaceutical Chemistry Research Laboratory, Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi 221 005, India.
Shrivastava SK; Pharmaceutical Chemistry Research Laboratory, Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi 221 005, India. Electronic address: skshrivastava.phe@itbhu.ac.in.

Bioorg Med Chem ; 27(7): 1327-1340, 2019 04 01.

Article em En | MEDLINE | ID: mdl-30795991

Assuntos

Inibidores da Colinesterase/farmacologia; Disfunção Cognitiva/tratamento farmacológico; Desenho de Fármacos; Oxidiazóis/farmacologia; Pirimidinas/farmacologia; Acetilcolinesterase/metabolismo; Animais; Butirilcolinesterase/metabolismo; Linhagem Celular; Inibidores da Colinesterase/síntese química; Inibidores da Colinesterase/química; Disfunção Cognitiva/metabolismo; Relação Dose-Resposta a Droga; Humanos; Camundongos; Modelos Moleculares; Estrutura Molecular; Oxidiazóis/síntese química; Oxidiazóis/química; Pirimidinas/síntese química; Pirimidinas/química; Relação Estrutura-Atividade

Palavras-chave

1,3,4-Oxadiazole; 2-Aminopyrimidine; Acetylcholinesterase; Antioxidant; Aß aggregation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oxidiazóis / Pirimidinas / Desenho de Fármacos / Inibidores da Colinesterase / Disfunção Cognitiva Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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