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Relapse of a group 4 medulloblastoma after 18 years as proven by histology and DNA methylation profiling.
Ricklefs, Franz L; Fritzsche, Friederike; Winkler, Beate; Meissner, Barbara; Dührsen, Lasse; Westphal, Manfred; Rutkowski, Stefan; Martens, Tobias; Schüller, Ulrich.
Afiliação
  • Ricklefs FL; Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
  • Fritzsche F; Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
  • Winkler B; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
  • Meissner B; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
  • Dührsen L; Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
  • Westphal M; Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
  • Rutkowski S; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
  • Martens T; Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
  • Schüller U; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany. u.schueller@uke.de.
Childs Nerv Syst ; 35(6): 1029-1033, 2019 06.
Article em En | MEDLINE | ID: mdl-30796558
BACKGROUND: Recent studies on medulloblastomas (MB) suggest that a large fraction of tumors appearing as late recurrence turn out to be secondary malignancies, e.g., malignant gliomas, after thorough molecular investigation. RESULTS: Here, we report of a patient with a group 4 MB that developed a distant recurrence after more than 18 years. The recurrent tumor was confirmed by histology and genome-wide DNA methylation profiling. CONCLUSION: Our case not only illustrates the potential of very late recurrences after seemingly cured group 4 MB, but also illustrates that detailed molecular analyses are indispensable in patients with a history of a previous malignancy.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Cerebelares / Meduloblastoma / Recidiva Local de Neoplasia Limite: Adolescent / Humans / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Cerebelares / Meduloblastoma / Recidiva Local de Neoplasia Limite: Adolescent / Humans / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article