A unique phenotype of T-cell acute lymphoblastic leukemia in a patient with GATA2 haploinsufficiency.
Pediatr Blood Cancer
; 66(6): e27649, 2019 06.
Article
em En
| MEDLINE
| ID: mdl-30802360
ABSTRACT
Germline or acquired mutations involving the GATA-binding protein gene (GATA2) have been linked to a variety of clinical conditions. In addition, patients harboring GATA2 mutations have a striking predisposition to develop myeloid malignancies, such as myelodysplastic syndrome or acute myeloid leukemia, but not acute lymphoblastic leukemia (ALL). We report here a unique occurrence of early T-cell precursor ALL in a young child with GATA2 haploinsufficiency.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Leucemia-Linfoma Linfoblástico de Células T Precursoras
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Haploinsuficiência
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Deficiência de GATA2
Tipo de estudo:
Etiology_studies
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Prognostic_studies
Limite:
Child
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Female
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Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article