Complex modifier landscape underlying genetic background effects.

Hou, Jing; Tan, Guihong; Fink, Gerald R; Andrews, Brenda J; Boone, Charles

Hou, Jing; Tan, Guihong; Fink, Gerald R; Andrews, Brenda J; Boone, Charles.

Afiliação

Hou J; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 3E1, Canada; jing.hou@utoronto.ca brenda.andrews@utoronto.ca charlie.boone@utoronto.ca.
Tan G; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 3E1, Canada.
Fink GR; Whitehead Institute for Biomedical Research, Cambridge, MA 02142.
Andrews BJ; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 3E1, Canada; jing.hou@utoronto.ca brenda.andrews@utoronto.ca charlie.boone@utoronto.ca.
Boone C; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 3E1, Canada; jing.hou@utoronto.ca brenda.andrews@utoronto.ca charlie.boone@utoronto.ca.

Proc Natl Acad Sci U S A ; 116(11): 5045-5054, 2019 03 12.

Article em En | MEDLINE | ID: mdl-30804202

Assuntos

Genes Modificadores; Patrimônio Genético; Saccharomyces cerevisiae/genética; Alelos; Vias Biossintéticas; Cisteína/biossíntese; Genes Essenciais; Genoma Fúngico; Filogenia; Saccharomyces cerevisiae/isolamento & purificação

Palavras-chave

background effect; complex modifier interactions; conditional gene essentiality; rare variants

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Saccharomyces cerevisiae / Genes Modificadores / Patrimônio Genético Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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