Expression of YY1 in Wilms tumors with favorable histology is a risk factor for adverse outcomes.
Future Oncol
; 15(11): 1231-1241, 2019 Apr.
Article
em En
| MEDLINE
| ID: mdl-30810052
ABSTRACT
AIM:
To investigate the role of the transcription factor YY1 in Wilms tumor (WT). PATIENTS &METHODS:
We measured YY1 expression using tissue microarray from patients with pediatric renal tumors, mainly WT and evaluated correlations with the predicted clinical evolution. YY1 expression was measured using immunohistochemical and protein expression was determined by digital pathology. RESULTS &CONCLUSION:
YY1 significantly increased in WT patients. In addition, an increase in YY1 expression had a greater risk of adverse outcomes in WT patients with favorable histology. YY1 expression was higher in the blastemal component of tumors, and high nuclear expression positively correlated with metastasis. YY1 may be considered as a metastasis risk factor in WT.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Expressão Gênica
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Fator de Transcrição YY1
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Neoplasias Renais
Tipo de estudo:
Etiology_studies
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Prognostic_studies
/
Risk_factors_studies
Limite:
Child
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Child, preschool
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Female
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Humans
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Infant
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Male
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article