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mTOR inhibition by metformin impacts monosodium urate crystal-induced inflammation and cell death in gout: a prelude to a new add-on therapy?
Vazirpanah, Nadia; Ottria, Andrea; van der Linden, Maarten; Wichers, Catharina G K; Schuiveling, Mark; van Lochem, Ellen; Phipps-Green, Amanda; Merriman, Tony; Zimmermann, Maili; Jansen, Matthijs; Radstake, Timothy R D J; Broen, Jasper C A.
Afiliação
  • Vazirpanah N; Department of Rheumatology and Clinical Immunology, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands nadiavazirpanah@gmail.com.
  • Ottria A; Department of Rheumatology and Clinical Immunology, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.
  • van der Linden M; Department of Rheumatology and Clinical Immunology, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.
  • Wichers CGK; Department of Rheumatology and Clinical Immunology, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.
  • Schuiveling M; Department of Rheumatology and Clinical Immunology, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.
  • van Lochem E; Medical Microbiology and Immunology, Rijnstate Hospital, Arnhem, The Netherlands.
  • Phipps-Green A; Department of Biochemistry, University of Otago, Dunedin, New Zealand.
  • Merriman T; Department of Biochemistry, University of Otago, Dunedin, New Zealand.
  • Zimmermann M; Department of Rheumatology and Clinical Immunology, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.
  • Jansen M; Department of Immunology, Rijnstate Hospital, Arnhem, The Netherlands.
  • Radstake TRDJ; Department of Rheumatology and Clinical Immunology, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.
  • Broen JCA; Department of Rheumatology and Clinical Immunology, University Medical Center, Utrech, The Netherlands.
Ann Rheum Dis ; 78(5): 663-671, 2019 05.
Article em En | MEDLINE | ID: mdl-30814053
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácido Úrico / Morte Celular / Serina-Treonina Quinases TOR / Gota / Metformina Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácido Úrico / Morte Celular / Serina-Treonina Quinases TOR / Gota / Metformina Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article