Copper-Catalyzed Oxydifluoroalkylation of Hydroxyl-Containing Alkenes.
J Org Chem
; 84(7): 4507-4516, 2019 04 05.
Article
em En
| MEDLINE
| ID: mdl-30816034
ABSTRACT
An efficient oxydifluoroalkylation of hydroxyl-containing alkenes using a copper catalytic system has been developed. This reaction proceeded through a one-pot process of difluoroalkylation followed by nucleophilic attack of the appended hydroxyl group. This strategy has the advantages of a low-cost catalyst and broad substrate scope, which provides a facile access to various fluoroalkylated tetrahydrofurans and tetrahydropyrans.
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MEDLINE
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article