Neuronal stretch reception - Making sense of the mechanosense.
Exp Cell Res
; 378(1): 104-112, 2019 05 01.
Article
em En
| MEDLINE
| ID: mdl-30817929
ABSTRACT
The sensation of mechanical force underlies many of our daily activities. As the sense of touch determines the quality of life, the subconscious sense of proprioception and visceral mechanosensation is indispensible for survival. Many internal organs change shape, either as an active part of their physiology or passively due to body movements. Importantly, these shape changes need to be sensed and balanced properly to prevent organ failure and dysfunction. Consequently, a failure to properly sense volume changes of internal organs has a huge clinical relevance, manifested by a plethora of congenital and age-related diseases. Here we review novel data on mammalian stretch reception as well as classical studies from insect and nematode proprioceptors with the aim to highlight the missing link between organ-level deformation and mechanosensing on the molecular level.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Mecanotransdução Celular
/
Mecanorreceptores
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article