Enhanced water solubility, antioxidant activity, and oral absorption of hesperetin by D-&#945;-tocopheryl polyethylene glycol 1000 succinate and phosphatidylcholine.

Gu, Su-Fang; Wang, Li-Ying; Tian, Ying-Jie; Zhou, Zhu-Xian; Tang, Jian-Bin; Liu, Xiang-Rui; Jiang, Hai-Ping; Shen, You-Qing

Enhanced water solubility, antioxidant activity, and oral absorption of hesperetin by D-α-tocopheryl polyethylene glycol 1000 succinate and phosphatidylcholine.

Gu, Su-Fang; Wang, Li-Ying; Tian, Ying-Jie; Zhou, Zhu-Xian; Tang, Jian-Bin; Liu, Xiang-Rui; Jiang, Hai-Ping; Shen, You-Qing.

Afiliação

Gu SF; Key Laboratory of Biomass Chemical Engineering of Ministry of Education and Center for Bionanoengineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.
Wang LY; Key Laboratory of Biomass Chemical Engineering of Ministry of Education and Center for Bionanoengineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.
Tian YJ; Hangzhou Ubao Healthcare Technology Co., Ltd., Hangzhou 310012, China.
Zhou ZX; Key Laboratory of Biomass Chemical Engineering of Ministry of Education and Center for Bionanoengineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.
Tang JB; Key Laboratory of Biomass Chemical Engineering of Ministry of Education and Center for Bionanoengineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.
Liu XR; Key Laboratory of Biomass Chemical Engineering of Ministry of Education and Center for Bionanoengineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.
Jiang HP; Department of Medical Oncology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.
Shen YQ; Key Laboratory of Biomass Chemical Engineering of Ministry of Education and Center for Bionanoengineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.

J Zhejiang Univ Sci B ; 20(3): 273-281, 2019.

Article em En | MEDLINE | ID: mdl-30829014

Assuntos

Antioxidantes/química; Hesperidina/química; Fosfatidilcolinas/química; Água/química; alfa-Tocoferol/química; Administração Oral; Animais; Disponibilidade Biológica; Varredura Diferencial de Calorimetria; Cães; Relação Dose-Resposta a Droga; Portadores de Fármacos; Feminino; Células Hep G2; Humanos; Luz; Células Madin Darby de Rim Canino; Micelas; Polietilenoglicóis/química; Ratos; Ratos Sprague-Dawley; Espalhamento de Radiação; Solubilidade; Solventes; Vitamina E/química

Palavras-chave

Hesperetin; D-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS); Phosphatidylcholine; Antioxidant activity; Oral absorption

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fosfatidilcolinas / Água / Alfa-Tocoferol / Hesperidina / Antioxidantes Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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