Abnormalities in chemokine receptor recycling in chronic lymphocytic leukemia.
Cell Mol Life Sci
; 76(16): 3249-3261, 2019 Aug.
Article
em En
| MEDLINE
| ID: mdl-30830241
ABSTRACT
In addition to their modulation through de novo expression and degradation, surface levels of chemokine receptors are tuned by their ligand-dependent recycling to the plasma membrane, which ensures that engaged receptors become rapidly available for further rounds of signaling. Dysregulation of this process contributes to the pathogenesis of chronic lymphocytic leukemia (CLL) by enhancing surface expression of chemokine receptors, thereby favoring leukemic cell accumulation in the protective niche of lymphoid organs. In this review, we summarize our current understanding of the process of chemokine receptor recycling, focusing on the impact of its dysregulation in CLL.
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Base de dados:
MEDLINE
Assunto principal:
Leucemia Linfocítica Crônica de Células B
/
Receptores de Quimiocinas
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article