Proteomic analysis reveals that wildtype and alanine-expanded nuclear poly(A)-binding protein exhibit differential interactions in skeletal muscle.

Banerjee, Ayan; Phillips, Brittany L; Deng, Quidong; Seyfried, Nicholas T; Pavlath, Grace K; Vest, Katherine E; Corbett, Anita H

Banerjee, Ayan; Phillips, Brittany L; Deng, Quidong; Seyfried, Nicholas T; Pavlath, Grace K; Vest, Katherine E; Corbett, Anita H.

Afiliação

Banerjee A; From the Department of Biology and.
Phillips BL; From the Department of Biology and.
Deng Q; the Graduate Program in Genetics and Molecular Biology, Emory University, Atlanta, Georgia 30322.
Seyfried NT; the Department of Biochemistry, Center for Neurodegenerative Diseases and.
Pavlath GK; the Department of Biochemistry, Center for Neurodegenerative Diseases and.
Vest KE; the Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, and.
Corbett AH; the Department of Molecular Genetics, Biochemistry & Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 katherine.vest@uc.edu.

J Biol Chem ; 294(18): 7360-7376, 2019 05 03.

Article em En | MEDLINE | ID: mdl-30837270

Assuntos

Alanina/metabolismo; Músculo Esquelético/metabolismo; Distrofia Muscular Oculofaríngea/metabolismo; Proteínas Nucleares/metabolismo; Proteína I de Ligação a Poli(A)/metabolismo; Proteômica; Animais; Células Cultivadas; Proteínas de Ligação a DNA/genética; Proteínas de Ligação a DNA/metabolismo; Eletroporação; Feminino; Masculino; Camundongos; Peso Molecular; Distrofia Muscular Oculofaríngea/genética; Proteína I de Ligação a Poli(A)/genética; Estudo de Prova de Conceito; Ligação Proteica

Palavras-chave

PABPN1; RNA-binding protein; TAR DNA-binding protein 43 (TDP-43) (TARDBP); gene regulation; muscular dystrophy; oculopharyngeal muscular dystrophy (OPMD); poly(A) polyalanine tract; protein aggregation; proteinprotein interaction; proteomics; skeletal muscle

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Nucleares / Músculo Esquelético / Distrofia Muscular Oculofaríngea / Proteína I de Ligação a Poli(A) / Proteômica / Alanina Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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