Impaired &#945;Vß8 and TGFß signaling lead to microglial dysmaturation and neuromotor dysfunction.

Arnold, Thomas D; Lizama, Carlos O; Cautivo, Kelly M; Santander, Nicolas; Lin, Lucia; Qiu, Haiyan; Huang, Eric J; Liu, Chang; Mukouyama, Yoh-Suke; Reichardt, Louis F; Zovein, Ann C; Sheppard, Dean

Impaired αVß8 and TGFß signaling lead to microglial dysmaturation and neuromotor dysfunction.

Arnold, Thomas D; Lizama, Carlos O; Cautivo, Kelly M; Santander, Nicolas; Lin, Lucia; Qiu, Haiyan; Huang, Eric J; Liu, Chang; Mukouyama, Yoh-Suke; Reichardt, Louis F; Zovein, Ann C; Sheppard, Dean.

Afiliação

Arnold TD; Department of Pediatrics, University of California, San Francisco, San Francisco, CA arnoldt@peds.ucsf.edu.
Lizama CO; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA.
Cautivo KM; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA.
Santander N; Department of Pediatrics, University of California, San Francisco, San Francisco, CA.
Lin L; Department of Pediatrics, University of California, San Francisco, San Francisco, CA.
Qiu H; Department of Pathology, University of California, San Francisco, San Francisco, CA.
Huang EJ; Department of Neurology, University of California, San Francisco, San Francisco, CA.
Liu C; Department of Pathology, University of California, San Francisco, San Francisco, CA.
Mukouyama YS; Department of Neurology, University of California, San Francisco, San Francisco, CA.
Reichardt LF; Laboratory of Stem Cell and Neuro-Vascular Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Zovein AC; Laboratory of Stem Cell and Neuro-Vascular Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Sheppard D; Department of Physiology and Neuroscience Program, University of California, San Francisco, San Francisco, CA.

J Exp Med ; 216(4): 900-915, 2019 04 01.

Article em En | MEDLINE | ID: mdl-30846482

Assuntos

Integrinas/metabolismo; Interneurônios/metabolismo; Microglia/metabolismo; Transdução de Sinais/genética; Fator de Crescimento Transformador beta1/metabolismo; Animais; Encéfalo/crescimento & desenvolvimento; Encéfalo/metabolismo; Feminino; Integrinas/genética; Locomoção/genética; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Transtornos do Neurodesenvolvimento/metabolismo; Oligodendroglia/metabolismo; Fenótipo; Receptor do Fator de Crescimento Transformador beta Tipo II/genética; Fator de Crescimento Transformador beta1/genética

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Integrinas / Microglia / Fator de Crescimento Transformador beta1 / Interneurônios Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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