Quantitative data on red cell measures of iron status and their relation to the magnitude of the systemic inflammatory response and survival in patients with colorectal cancer.
Eur J Surg Oncol
; 45(7): 1205-1211, 2019 Jul.
Article
em En
| MEDLINE
| ID: mdl-30850153
ABSTRACT
BACKGROUND:
Inflammation is recognised to be associated with perturbation of serum measures of iron status. However, the impact of colorectal cancer associated host inflammation on red cell measures of iron status has not been previously quantified.METHODS:
Patients undergoing elective surgery with curative intent, for colorectal cancer, at a single centre between 2008 and 2017 were included (nâ¯=â¯824). Blood samples taken for C-reactive protein (CRP), albumin, and full blood count (FBC) allowed patients to be grouped by modified Glasgow Prognostic Score (mGPS), and anaemia subtype (haemoglobin (Hb) Mâ¯<â¯130â¯mg/L and Fâ¯<â¯120â¯mg/L, with microcytic anaemia being mean corpuscular volume (MCV)â¯<â¯80 f/L, and normocytic anaemia with MCV 80-100 f/L). Relationships between these groupings and red cell measures iron status including Hb, MCV, mean corpuscular haemoglobin (MCH) and red cell distribution width (RDW) were examined.RESULTS:
The combination of increasing T stage and increasing mGPS was associated with lower Hb, lower MCV, lower MCH, higher RDW, and higher prevalence of both microcytic and normocytic anaemia (all pâ¯<â¯0.001). The combination of CRP >10â¯mg/L and albumin <35â¯â¯g/L was associated with lower Hb, lower MCV, lower MCH, higher RDW, and higher prevalence of both microcytic and normocytic anaemia (all pâ¯<â¯0.010). At multivariate Cox regression only Hb remained significantly associated with cancer specific (HR 0.98, 95% CI 0.97-0.99, pâ¯<â¯0.001), and overall survival (HR 0.98, 95% CI 0.97-0.99, pâ¯=â¯0.001).CONCLUSIONS:
The presence of a host systemic inflammatory response to colorectal cancer was associated with significant perturbation of red cell measure of iron status.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Hemoglobinas
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Neoplasias Colorretais
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Índices de Eritrócitos
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Inflamação
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Anemia
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article