Guillain-Barré syndrome as a complication of hypertensive basal ganglia haemorrhage.
J Clin Neurosci
; 64: 54-56, 2019 Jun.
Article
em En
| MEDLINE
| ID: mdl-30852075
ABSTRACT
We aimed to study the potential relationship of Guillain-Barré syndrome (GBS) and intracranial haemorrhage (ICH). We present a case of a 70-year-old hypertensive woman who developed global weakness, eventually becoming quadriplegic, during an inpatient stay for treatment of a basal ganglia haemorrhagic stroke. Guillain-Barré syndrome was confirmed and treatment initiated. She responded well to intravenous immunoglobulin treatment and then subsequently continued with rehabilitation. There have been a few case reports of GBS as a complication of spontaneous intracranial haemorrhage (ICH) or traumatic brain injury. It may not be a coincidence that our patient developed GBS shortly after presentation. There may be an immunological explanation with immune activation following neuronal injury after ICH with associated blood-brain barrier breakdown. GBS following ICH adds further complexity to treating patients who are already critically ill. If patients develop new weakness after ICH, there should be a high index of suspicion for GBS. It should be distinguished from critical illness neuropathy/myopathy and other causes of weakness in critical care patients because the treatment is very different. Immune activation and sensitization to myelin-associated proteins may be the underlying pathophysiological basis.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Síndrome de Guillain-Barré
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Hemorragia dos Gânglios da Base
Limite:
Aged
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Female
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Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article