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Vitamin B12 modulates Parkinson's disease LRRK2 kinase activity through allosteric regulation and confers neuroprotection.
Schaffner, Adam; Li, Xianting; Gomez-Llorente, Yacob; Leandrou, Emmanouela; Memou, Anna; Clemente, Nicolina; Yao, Chen; Afsari, Farinaz; Zhi, Lianteng; Pan, Nina; Morohashi, Keita; Hua, Xiaoluan; Zhou, Ming-Ming; Wang, Chunyu; Zhang, Hui; Chen, Shu G; Elliott, Christopher J; Rideout, Hardy; Ubarretxena-Belandia, Iban; Yue, Zhenyu.
Afiliação
  • Schaffner A; Department of Neurology and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Li X; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Gomez-Llorente Y; Department of Neurology and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Leandrou E; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Memou A; Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.
  • Clemente N; Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.
  • Yao C; Department of Biological Sciences, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, 12180, USA.
  • Afsari F; Department of Pathology, Case Western Reserve University, Cleveland, OH, 44106, USA.
  • Zhi L; Department of Biology, University of York, York, YO1 5DD, UK.
  • Pan N; Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
  • Morohashi K; Department of Neurology and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Hua X; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Zhou MM; Department of Neurology and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Wang C; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Zhang H; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Chen SG; Department of Biological Sciences, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, 12180, USA.
  • Elliott CJ; Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
  • Rideout H; Department of Pathology, Case Western Reserve University, Cleveland, OH, 44106, USA.
  • Ubarretxena-Belandia I; Department of Biology, University of York, York, YO1 5DD, UK.
  • Yue Z; Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.
Cell Res ; 29(4): 313-329, 2019 04.
Article em En | MEDLINE | ID: mdl-30858560
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Vitamina B 12 / Complexo Vitamínico B / Cobamidas / Fármacos Neuroprotetores / Serina-Treonina Proteína Quinase-2 com Repetições Ricas em Leucina Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Vitamina B 12 / Complexo Vitamínico B / Cobamidas / Fármacos Neuroprotetores / Serina-Treonina Proteína Quinase-2 com Repetições Ricas em Leucina Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article