A multiplexable assay for screening antibiotic lethality against drug-tolerant bacteria.
Nat Methods
; 16(4): 303-306, 2019 04.
Article
em En
| MEDLINE
| ID: mdl-30858599
ABSTRACT
Antibiotic screens typically rely on growth inhibition to characterize compound bioactivity-an approach that cannot be used to assess the bactericidal activity of antibiotics against bacteria in drug-tolerant states. To address this limitation, we developed a multiplexed assay that uses metabolism-sensitive staining to report on the killing of antibiotic-tolerant bacteria. This method can be used with diverse bacterial species and applied to genome-scale investigations to identify therapeutic targets against tolerant pathogens.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Bactérias
/
Testes de Sensibilidade Microbiana
/
Farmacorresistência Bacteriana
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Escherichia coli
/
Antibacterianos
Tipo de estudo:
Diagnostic_studies
/
Screening_studies
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article