GenCoNet - A Graph Database for the Analysis of Comorbidities by Gene Networks.
J Integr Bioinform
; 15(4)2018 Dec 25.
Article
em En
| MEDLINE
| ID: mdl-30864352
ABSTRACT
The prevalence of comorbid diseases poses a major health issue for millions of people worldwide and an enormous socio-economic burden for society. The molecular mechanisms for the development of comorbidities need to be investigated. For this purpose, a workflow system was developed to aggregate data on biomedical entities from heterogeneous data sources. The process of integrating and merging all data sources of the workflow system was implemented as a semi-automatic pipeline that provides the import, fusion, and analysis of the highly connected biomedical data in a Neo4j database GenCoNet. As a starting point, data on the common comorbid diseases essential hypertension and bronchial asthma was integrated. GenCoNet (https//genconet.kalis-amts.de) is a curated database that provides a better understanding of hereditary bases of comorbidities.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Asma
/
Gráficos por Computador
/
Software
/
Bases de Dados Factuais
/
Biologia Computacional
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Redes Reguladoras de Genes
/
Hipertensão Essencial
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article