"On Water" Direct Organocatalytic Cyanoarylmethylation of Isatins for the Diastereoselective Synthesis of 3-Hydroxy-3-cyanomethyl Oxindoles.
J Org Chem
; 84(7): 4000-4008, 2019 04 05.
Article
em En
| MEDLINE
| ID: mdl-30864430
ABSTRACT
An "on water" organocatalytic cyanoarylmethylation of aryl acetonitrile to isatins is developed, giving products in high yields and up to excellent diastereoselectivities. A remarkable enhancement of reaction rates and diastereoselectivities by water was observed under mild conditions. Moreover, this approach provides a highly efficient and environmentally benign access to thermodynamic 3-hydroxy-3-cyanomethyl oxindoles.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Acetonitrilas
/
Água
/
Oxindóis
/
Isatina
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article