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Osteoporosis and the Ageing Skeleton.
Aspray, Terry J; Hill, Tom R.
Afiliação
  • Aspray TJ; NIHR Biomedical Research Centre, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK. Terry.Aspray@Newcastle.ac.uk.
  • Hill TR; Institute of Cellular Medicine, Newcastle University, Newcastle-Upon-Tyne, UK. Terry.Aspray@Newcastle.ac.uk.
Subcell Biochem ; 91: 453-476, 2019.
Article em En | MEDLINE | ID: mdl-30888662
Osteoporosis is a "skeletal disorder characterized by compromised bone strength predisposing a person to an increased risk of fracture" which, in light of demographic change, is becoming an increasing burden on health care worldwide. Increasing age and female gender are associated with the condition, although a wider range of clinical risk factors are being used increasingly to identify those at risk of osteoporosis and its most important sequelae, fracture.While osteoporosis and fracture have long been associated with women in the post-menopausal age, fracture incidence increases because of the ageing of our population. Interventions to abate the progression of osteoporosis and to prevent fractures must focus on the old and the very old. Evidence associating nutritional factors, particularly calcium and vitamin D are reviewed as are the association of falls risk with fracture and the potential for interventions to prevent falls. Finally, the assessment of frailty in the oldest old, associated sarcopenia and multi-morbidity are considered in the evaluation of fall and fracture risk and the management of osteoporosis in the ninth decade of life and beyond.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Envelhecimento / Osteoporose Pós-Menopausa Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Envelhecimento / Osteoporose Pós-Menopausa Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article