Inhibition of diverse opportunistic viruses by structurally optimized retrograde trafficking inhibitors.
Bioorg Med Chem
; 27(9): 1795-1803, 2019 05 01.
Article
em En
| MEDLINE
| ID: mdl-30890396
ABSTRACT
Opportunistic viruses are a major problem for immunosuppressed individuals, particularly following organ or stem cell transplantation. Current treatments are non-existent or suffer from problems such as high toxicity or development of resistant strains. We previously published that a trafficking inhibitor that targets a host protein greatly reduces the replication of human cytomegalovirus. This inhibitor was also shown to be moderately effective against polyomaviruses, another family of opportunistic viruses. We have developed a panel of analogues for this inhibitor and have shown that these analogues maintain their high efficacy against HCMV, while substantially lowering the concentration required to inhibit polyomavirus replication. By targeting a host protein these compounds are able to inhibit the replication of two very different viruses. These observations open up the possibility of pan-viral inhibitors for immunosuppressed individuals that are effective against multiple, diverse opportunistic viruses.
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Base de dados:
MEDLINE
Assunto principal:
Antivirais
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Replicação Viral
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Citomegalovirus
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article