KGF-1 accelerates wound contraction through the TGF-ß1/Smad signaling pathway in a double-paracrine manner.

Peng, Yi; Wu, Song; Tang, Qiyu; Li, Shuaihua; Peng, Cheng

Peng, Yi; Wu, Song; Tang, Qiyu; Li, Shuaihua; Peng, Cheng.

Afiliação

Peng Y; Department of Plastic Surgery and Orthopedic Surgery, Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China; Orthopedic Surgery, Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China.
Wu S; Orthopedic Surgery, Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China.
Tang Q; Department of Plastic Surgery and Orthopedic Surgery, Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China.
Li S; Department of Cosmetic and Plastic Surgery, First People's Hospital of Chenzhou, Chenzhou, Hunan 423000, China.
Peng C; Department of Plastic Surgery and Orthopedic Surgery, Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China. Electronic address: pcheng83@csu.edu.cn.

J Biol Chem ; 294(21): 8361-8370, 2019 05 24.

Article em En | MEDLINE | ID: mdl-30894415

Assuntos

Complicações do Diabetes/metabolismo; Diabetes Mellitus Experimental/metabolismo; Fator 7 de Crescimento de Fibroblastos/metabolismo; Proteína Smad2/metabolismo; Proteína Smad3/metabolismo; Fator de Crescimento Transformador beta1/metabolismo; Cicatrização; Animais; Linhagem Celular; Meios de Cultivo Condicionados; Complicações do Diabetes/tratamento farmacológico; Complicações do Diabetes/patologia; Diabetes Mellitus Experimental/tratamento farmacológico; Diabetes Mellitus Experimental/patologia; Fator 7 de Crescimento de Fibroblastos/farmacologia; Fibroblastos/metabolismo; Humanos; Masculino; Camundongos; Ratos; Ratos Sprague-Dawley

Palavras-chave

cell migration; cell proliferation; cellcell interaction; diabetic wound; epithelialmesenchymal interaction; transforming growth factor ß (TGF-ß); wound contraction; wound healing

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cicatrização / Complicações do Diabetes / Diabetes Mellitus Experimental / Fator 7 de Crescimento de Fibroblastos / Proteína Smad2 / Proteína Smad3 / Fator de Crescimento Transformador beta1 Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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