Size-controlled synthesis of polymerized DNA nanoparticles for targeted anticancer drug delivery.
Chem Commun (Camb)
; 55(34): 4905-4908, 2019 Apr 23.
Article
em En
| MEDLINE
| ID: mdl-30901006
ABSTRACT
We synthesized size-tunable polymerized DNA nanoparticles (PDNs) for cancer-targeted drug delivery via sequential processes of rolling circle amplification, condensation, and layer-by-layer assembly. The PDNs selectively delivered anti-sense oligonucleotides to target cancer cells and exhibited size-dependent gene regulation efficacy.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Ovarianas
/
DNA
/
Sistemas de Liberação de Medicamentos
/
Nanopartículas
/
Carcinoma Epitelial do Ovário
/
Antineoplásicos
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article