RNA Circularization Diminishes Immunogenicity and Can Extend Translation Duration In Vivo.

Wesselhoeft, R Alexander; Kowalski, Piotr S; Parker-Hale, Frances C; Huang, Yuxuan; Bisaria, Namita; Anderson, Daniel G

RNA Circularization Diminishes Immunogenicity and Can Extend Translation Duration In Vivo.

Wesselhoeft, R Alexander; Kowalski, Piotr S; Parker-Hale, Frances C; Huang, Yuxuan; Bisaria, Namita; Anderson, Daniel G.

Afiliação

Wesselhoeft RA; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Kowalski PS; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Parker-Hale FC; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Department of Political Science, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Huang Y; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Bisaria N; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
Anderson DG; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Institute for Medical Engineering and Science, Massachusetts Institute of Tec

Mol Cell ; 74(3): 508-520.e4, 2019 05 02.

Article em En | MEDLINE | ID: mdl-30902547

Assuntos

Proteína DEAD-box 58/genética; Biossíntese de Proteínas; RNA Mensageiro/genética; RNA/genética; Animais; Proteína DEAD-box 58/imunologia; Regulação da Expressão Gênica; Redes Reguladoras de Genes/genética; Imunidade Inata/genética; Camundongos; MicroRNAs/genética; RNA Circular; Receptores Toll-Like/genética; Receptores Toll-Like/imunologia; Uridina/genética; Vacinas Sintéticas/genética

Palavras-chave

RIG-I; RNA sensors; circular RNA; immunogenicity; protein expression; synthetic

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Biossíntese de Proteínas / RNA / RNA Mensageiro / Proteína DEAD-box 58 Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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